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Concepts in B cell acute lymphoblastic leukemia pathogenesis

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Clarissa Garcia, Megan D Miller-Awe, Matthew T Witkowski

Journal of Leukocyte Biology (2024)

Flow cytometric assessment of leukemia-associated monocytes in childhood B-cell acute lymphoblastic leukemia outcome


NUDT21 limits CD19 levels through alternative mRNA polyadenylation in
B cell acute lymphoblastic leukemia


Witkowski MT*, Lee S*, Wang E*, Lee AK, Talbot A, Ma C,  Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG,  Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J & Aifantis I.

Nature Immunology (2022)

Extensive Remodeling of the Immune Microenvironment in B-cell Acute Lymphoblastic Leukemia


Witkowski MT*, Dolgalev I*, Evensen NA, Ma C, Chambers T, Roberts CG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL & Aifantis I.

Cancer Cell (2020)

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome


Witkowski MT, Hu Y, Roberts KG, Boer JM, McKenzie MD, Liu GJ, Le Grice OD, Tremblay CS, Ghisi M, Willson TA, Horstmann MA, Aifantis I, Cimmino L, Frietze S, den Boer ML, Mullighan CG, Smyth GK, Dickins RA.

J Exp Med (2017)

Activated Notch Signaling counteracts Ikaros tumor suppression in mouse and human T cell acute lymphoblastic leukemia

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Witkowski MT*, Cimmino L*, Hu, Y, Trimarchi T, Tagoh H, McKenzie MD, Best SA, Tuohey L, Willson TA, Nutt SL, Busslinger M, Aifantis I, Smyth GK, Dickins RA.

Leukemia (2015)

Review Articles

Single-cell analysis of acute lymphoblastic and lineage ambiguous leukemia – approaches and molecular insights


Iacobucci I, Witkowski MT, Mullighan CG

Blood (2023)

Mapping and targeting of the leukemic microenvironment.


Witkowski MT, Kousteni S, Aifantis I.

J Exp Med (2020)

Immune-Based Therapies in Acute Leukemia.


Witkowski MT*, Lasry A*, Carroll WL, Aifantis I.

Trends in Cancer (2019)

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